Consistent with an immunosuppressive tumor microenvironment, the HPV16_E6_101-specific T cells expressed factors associated with immune suppression including FOXP3, KLRC1 (NKG2A), and LGALS3 (galectin 3) and low levels of AIMs including CCL3, CCL4, and IFNG compared to the other virus-specific clusters, suggesting that the HPV16_E6_101-specific T cells might not be able to optimally respond to cognate ligand stimulation. Here, LGALS3 is linked to neoplasm.