Evidence based on specimens from patients with pharmacoresistant temporal lobe epilepsy and epilepsy models suggests that astrocytes in hippocampal sclerotic areas show a decreased expression of inwardly rectifying K+ (Kir) channels, particularly Kir4.1, leading to a decrease in spatial K+ buffering and an increase in neuronal excitation, contributing to seizure generation and epilepsy (Gabriel et al. 1998; Kovács et al. 2012; Steinhäuser et al. 2012; Wallraff et al. 2006). Here, KCNJ10 is linked to temporal lobe epilepsy.