AD is defined by its 2 pathological hallmarks, extracellularly amyloid-beta (amyloid-β) plaques and intracellularly neurofibrillary tangles (NFTs) of hyperphosphorylated tau, accompanied by progressive neurodegeneration especially in medial temporal lobe structures (Jack et al. 2018; DeTure and Dickson 2019). Here, MAPT is linked to Alzheimer disease.