ASPH and Anxiety: The functional importance of specific subpopulations of Hcrt neurons in mediating these behaviors is suggested by results from our recent report in zebrafish9, showing that ablation of the ectopic POA Hcrt neurons or the Hcrt neurons in the most anterior part of the aAH blocks the EtOH-induced increase in anxiety-like behavior, and ablation of the ectopic Hcrt neurons but not the aAH Hcrt neurons blocks the EtOH-induced increase in locomotor behavior.