Comparison of cluster composition between NAC and NAPC identified that CD4-C2-IL7R, CD8-C5-IL7R and CD8-C8-KLRG1 clusters tended to increase in NAPC tumor lesions after neoadjuvant therapy, while CD4-C11-FOXP3 clusters tended to decrease (Fig. 1d, e). The gene discussed is CD8A; the disease is neoplasm.