CXCR3 and neoplasm: In contrast, CD8+ T cells in the NAPC group highly expressed the chemokine receptor CXCR3 (Fig. 2c), which is a receptor for chemokines CXCL9, CXCL10, and CXCL11 and is responsible for recruiting CD8+ T cells to infiltrate into tumor tissues, proposing the potential that the combination of PD-1 blockade to NAC may attract more CD8+ T cells into tumor tissue to exert anti-tumor effects16.