The expression level of intra-tumor inflammatory cytokines19 was also associated with the therapy response in NAPC, with anti-inflammatory cytokines (such as IL1RN, IL5, IL10, IL13 and TGFB1) enriched in non-MPR and pro-inflammatory cytokines (such as IL1B, IL2, IL6, IL7, IL8, IL17A, and IL18) enriched in MPR tumor lesions (Fig. 2f). This evidence concerns the gene IL6 and neoplasm.