GIGYF1 and type 2 diabetes mellitus: Other notable phenome-wide-significant associations include type 2 diabetes and related phenotypes for GIGYF1 (refs. 36,37), chlorpromazine (antipsychotic) use and impaired cognitive function and awareness (ICD-10 code R41.8) for ADGRB2 (Supplementary Fig. 3 and Supplementary Table 9).