Rao et al. formulated a di-block polymer of Poly-lactic-co-glycolic acid (PLGA) and hetero bi-functional COOH-PEG-NH2, embedded with an imidazotetrazine alkylating agent (TMZ), and conjugated to a ligand (polysorbate-80/transferrin) and a stem cell targeting moiety (anti-nestin antibody).169 Such nanocomposites having targeting ligands could deliver TMZ to intracerebral glioblastoma xenografts and present favorable pharmacokinetics and anti-cancer potential. This evidence concerns the gene TF and glioblastoma.