TFRC and neoplasm: Significant enhancement of the brain distribution of DOX-loaded liposomes as well as higher anti-tumor efficacy were found.253 Quan et al. developed transferrin receptor aptamer-functionalized liposomes to deliver acetylcholinesterase reactivator in brain (Fig. 6a).254 Compared with non-targeting liposomes, this functionalized system has higher BBB penetration efficiency confirmed by both in vitro BBB model and in vivo biodistribution study.