Gómez-Ruiz and co-workers prepared a MSNs-based nanoplatform for delivery of a cocktail of agents (leptin and pioglitazone) to fight against amyotrophic lateral sclerosis.341 Leptin, a polypeptide hormone possessing neuroprotective effects, was conjugated with -NH2 of MSNs through EDC/NHS coupling, and pioglitazone, an anti-inflammatory agent, was loaded through adsorption. Here, LEP is linked to amyotrophic lateral sclerosis.