TFRC and central nervous system cancer: Qi et al. used RI7217, a monoclonal antibody from mouse, which shows high selectivity and sensitivity for the transferrin receptor, to modify long-circulating liposomes (Fig. 3b, c).170 In their research, hCMEC/D3 cells and U87-MG glioma cells were used to evaluate the uptake and mechanism of the targeted liposomes, and intracranial U87-MG glioma was used to test the capacity of the targeted liposomes to cross the BBB and anti-tumor.