With each unit increase in the AHI, the level of insulin resistance increased by 0.5%.529,530 In vivo kinetic studies of glucose metabolism have also demonstrated that severe OSAS impairs insulin sensitivity, glucose effectiveness, and pancreatic β-cell function.531 Oxidative stress and inflammation induced by intermittent hypoxemia in patients with OSAS may be key factors in insulin resistance. The gene discussed is INS; the disease is Insulin resistance.