LEP and COVID-19: After addressing possible confounders, the most recent study found that OSAS was associated with a twofold increased risk of severe COVID-19, a finding that could not be explained by obesity or other comorbidities.570 These current findings strongly suggest that OSAS is an independent factor contributing to the risk of more severe COVID-19.568,570,571 The most damaging complication during COVID-19 is the cytokine storm involving IL, TNF-α, CRP, leptin, and ferritin.