G0 is called the reference sequence APOL1 allele or wild-type.25 In the kidney, G0 expression contributes to maintaining podocyte phenotype and integrity.24 There are two genetic variants for two different isoforms of the APOL1, G1 and G2, that are associated with kidney disease,26 FSGS,27 HIV nephropathy,28 and other forms of nondiabetic kidney disease in patients of African ancestry.29 We analyzed cases of FSGS reported in association with COVID-19 infection from the beginning of the pandemic until November 2022. The gene discussed is APOL1; the disease is HIV-associated nephropathy.