A recent study from The Netherlands developed a logistic regression model using f-Hb, age and sex to calculate risk of advanced neoplasia.11 Individualised thresholds based on 96.9% specificity, ranging from 36.9 μg Hb/g faeces for a 50-year-old female to 9.5 μg Hb/g faeces for a 75-year-old male, were identified to give all participants a comparable risk of advanced neoplasia (CRC plus advanced adenoma: AA) prior to colonoscopy. The gene discussed is GSTM1; the disease is colorectal carcinoma.