recently discovered that cancer‐type OATP1B3 protein, a splice variant of liver‐type OATP1B3, is localized in the lysosomal membrane of colorectal cancer (CRC) cells and contributes to the transport of encorafenib and vemurafenib into lysosomes, resulting in decreased drug concentrations in the cytoplasm and reduced drug efficacy.115. This evidence concerns the gene SLCO1B3 and colorectal carcinoma.