Its essential feature is the loss of the expression of epithelial markers, such as E‐cadherin, β‐catenin, tight junction protein, and epithelial cell adhesion molecules on the cell membrane of cancer cells,350, 351, 352, 353 and meanwhile obtaining a mesenchymal phenotype with the increased expression of vimentin, N‐cadherin, fibronectin, and β1 and β3 integrins.354, 355, 356. This evidence concerns the gene FN1 and cancer.