HELLS and lung cancer: In addition, in lung cancer, lymphoid‐specific helicase (LSH), a protein belonging to the sucrose nonfermenting 2 family of chromatin‐remodeling enzymes, directly modifies DNA methylation with WD repeat domain 76 (WDR76) to activate metabolic genes, including GLUT1, FADS2, and SCD1, inhibiting ferroptosis by decreasing lipid ROS levels.103