In addition, in lung cancer, lymphoid‐specific helicase (LSH), a protein belonging to the sucrose nonfermenting 2 family of chromatin‐remodeling enzymes, directly modifies DNA methylation with WD repeat domain 76 (WDR76) to activate metabolic genes, including GLUT1, FADS2, and SCD1, inhibiting ferroptosis by decreasing lipid ROS levels.103. The gene discussed is HELLS; the disease is lung carcinoma.