HIC1 and liver cancer: In addition, in liver cancer, two transcription factors, hepatocyte nuclear factor 4 alpha (HNF4A) and HIC ZBTB transcriptional repressor 1 (HIC1), competitively bind with KAT2B, playing opposite roles regulating GSH production; the former has been identified a ferroptosis inhibitor, and the latter has been identified a ferroptosis inducer.73