KEAP1 and Hepatic fibrosis: Finally, in the CCL4-induced rat hepatic fibrosis model, the YJSB drug group activated the Keap1-Nrf2 signaling pathway, resulting in Keap1 release in the cytoplasm and Nrf2 entry into the nucleus to initiate a series of antioxidant reactions and promote the generation of antioxidant proteins.