Second, the activation of hepatic stellate cells by cytokines and other mediators is considered to be an important event in the pathophysiology of liver fibrosis and activated hepatic stellate cells or myofibroblasts are the primary sources of ECM molecules, including collagen, non-collagen glycoprotein, proteoglycan, and glycosaminoglycan (Chhimwal et al., 2020). This evidence concerns the gene ART4 and Hepatic fibrosis.