NFKB1 and myocardial infarction: However, other studies have suggested that cardiac function was improved after myocardial infarction in absence of NF-kB p50 subunit (13), showing that suppressing NF-kB with oligonucleotide decoys reduces ischemia-reperfusion (IR) myocardial injury (14) and TRAF2 mediates enhanced cardiac hypertrophy via activation of AKT/GSK3β signaling (15).