Wang 2014 provided a novel mechanism for the exosomal miR-320 functionally downregulated its target genes IGF-1, Hsp20, and Ets2 (IGF-1, insulin-like growth factor; Hsp20, heat shock proteins acting in myocytes as chaperons; Ets2, belonging to the ETS family of transcription factors, is implicated in a broad range of cellular functions underlying diabetes mellitus-induced myocardial vascular deficiency caused by secretion of anti-angiogenic exosomes from cardiomyocytes) (67). Here, IGF1 is linked to diabetes mellitus.