In addition, other transcription factors showed favorable trends by PICSO, as MeF2a (myocyte enhancer factor 2a), a prominent member of the transcription family, acting as a myocardial enhancer in cardiac development and adaption to hypertension-induced cardiac hypertrophy, although not statistically significant, due to the small number of patient tested (57). This evidence concerns the gene MEF2A and hypertensive disorder.