Gray Level Co-occurrence Matrix (GLCM) textural parameters applied to (R)-[11C]PK11195 PET images can provide a statistical description of the spatial characteristics of TSPO.49 Accordingly, the present study hypothesizes that whole-brain (grey and white matter) GLCM-based textural parameters may be an alternative to ROI-based kinetic modelling in (R)-[11C]PK11195 PET images in Alzheimer’s disease. Here, TSPO is linked to Alzheimer disease.