Khera et al. (2019) found that 83% of the high-risk group of PRSBMI were obese and overweight, while the remaining 17% had a normal BMI range or were underweight. Chen et al. (2021) constructed PRS for ALT, PRSALT and found that the disease risks (or ORs) between the groups of the bottom 10% and the top 10% of PRSALT were 1.88 for cirrhosis, and 1.67 for hepatic steatosis. Here, GPT is linked to fatty liver disease.