Mutations in metabolic genes are common in AML, such as mutations in isocitrate dehydrogenase 1 and 2 (IDH1, IDH2), key enzymes in the TCA cycle (Ragon and DiNardo, 2017; Cerchione et al., 2021; Issa and DiNardo, 2021). The gene discussed is IDH1; the disease is acute myeloid leukemia.