RHCE and fetal erythroblastosis: The most recent nationwide estimate of Rh-induced HDFN dates back to the 1980s, shortly after the introduction of RhD immune globulin prophylaxis in the 1970s, which dramatically changed the rates of RhD alloimmunized (at-risk) pregnancies from approximately 13%–16% to 0.5%–1.8% after the introduction of postpartum administration of RhD immune globulin and to 0.14% to 0.2% with routine antepartum administration.6