In a study by Işik and Barut34, in 2020 on 123 CRC patients, HER2 overexpression was found in 13% of patients, and HER2 overexpression showed a significant association with distant metastasis (P<0.05) and showed no relationship with age, sex, tumor site, or grade of the tumor. The gene discussed is ERBB2; the disease is neoplasm.