In the combination group, the most common AEs were fatigue (8.45%), URTI (8.45%), hypokalemia (7.04%), increased ALT (5.63%), pyrexia (2.82%), increased AST (2.82%), increased bilirubin (2.82%), insomnia (1.41%), hypertension (1.41%), hyperglycemia (1.41%), and urinary tract infections (1.41%). This evidence concerns the gene GPT and hypertensive disorder.