TKT and hepatocellular carcinoma: The knockdown of TKT expression affects HCC cells in multiple ways; it sensitizes HCC cells to sorafenib, suppresses cell proliferation and lung metastasis, decreases glucose uptake in vitro, alters glutathione metabolism, increases intracellular ROS levels, and induces oxidative stress-related G1 phase arrest (Xu et al., 2016).