Interestingly, BACH1 deficiency promotes E-cadherin expression in AsPC−1 (derived from ascitic fluid of pancreatic cancer) and SW1990 cells (derived from splenic metastases of pancreatic cancer), but inhibits E-cadherin expression in CFPAC-1 (derived from liver metastases of pancreatic cancer) and BXPC-3 cells (derived from orthotopic pancreatic cancer) (Huang et al., 2018; Sato et al., 2020). Here, BACH1 is linked to familial pancreatic carcinoma.