In this review, we summarize the pathophysiological role of BACH proteins in digestive system diseases including hepatitis C virus (HCV) infection, nonalcoholic steatohepatitis (NASH), hepatic and intestinal injury induced by drugs and other causes, immune-mediated intestinal diseases [inflammatory bowel disease (IBD) and celiac diseas], biliopancreatic diseases, and digestive system cancers (Table 1). The gene discussed is ACOT7; the disease is metabolic dysfunction-associated steatohepatitis.