TP63 and ectodermal dysplasia syndrome: Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 EEC3 (#604292 Maas et al., 1996; Celli et al., 1999; Rinne et al., 2006; Kosaki et al., 2008), ankyloblepharon-ectodermal defects, cleft lip/palate syndrome AEC (#106260), Rapp-Hodgkin (#129400), Acro dermatoungual lacrimal tooth syndrome ADULT (#103285), SHFM4 (#605289), Hay-Wells syndrome (#106260), and limb-mammary syndrome (#603543) are autosomal dominant allelic conditions due to mutations in the same gene, namely, TP63 (15 exons, 3q28) (Yang et al., 1999) encoding tumor protein 63.