Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 EEC3 (#604292 Maas et al., 1996; Celli et al., 1999; Rinne et al., 2006; Kosaki et al., 2008), ankyloblepharon-ectodermal defects, cleft lip/palate syndrome AEC (#106260), Rapp-Hodgkin (#129400), Acro dermatoungual lacrimal tooth syndrome ADULT (#103285), SHFM4 (#605289), Hay-Wells syndrome (#106260), and limb-mammary syndrome (#603543) are autosomal dominant allelic conditions due to mutations in the same gene, namely, TP63 (15 exons, 3q28) (Yang et al., 1999) encoding tumor protein 63. Here, TP63 is linked to limb-mammary syndrome.