Moreover, chromatin immunoprecipitation (ChIP) assays revealed that c-MYC the binding of to the PD-L1 promoter resulted in elevated PD-L1 expression in esophageal squamous cell carcinoma (ESCC) cells.71 Atsaves et al72 found that PD-L1 was upregulated in response to MYC overexpression in anaplastic large-cell lymphoma; however, MYC deficiency may increase PD-L1 expression through IFN-γ-mediated STAT1 upregulation in HCC.73 MYC blockade using MYCi361 can enhance CD3+ T-cell infiltration and increase tumor growth, while elevating PD-L1 expression in the tumor microenvironment.74 This evidence concerns the gene IFNG and hepatocellular carcinoma.