CD274 and myelodysplastic syndrome: Activation of NF-κB by IFN-γ or TNF-α can promote B7-H1 expression on myelodysplastic syndromes blasts.84 Additionally, activated NF-κB is involved in PD-L1 expression stimulated by lipopolysaccharide (LPS) in gastric cancer cells.85 There is conclusive evidence from several reports that binding of MYC and NF-κB p65 to the PD-L1 promoter enhanced PD-L1 expression via MUC1-C in TNBC, as well as by interferon-inducible 16 in cervical cancer cells and LPS-treated monocytes.86–88