ARID1A and hepatocellular carcinoma: AT-rich interaction domain 1A (ARID1A) is a prominent component of the SWI/SNF remodeling complex, and ARID1A deficiency results in elevated PD-L1 expression via PI3K/AKT signaling in HCC cells.104 Similarly, high PD-L1 levels were closely related to ARID1A deficiency in 273 patients with advanced gastric cancer.