Dysregulation of the PI3K-AKT pathway increases the survival and proliferation of various cancer cells.54 PI3K activation converts phosphatidylinositol 4,5-bisphosphate (PI-4,5-P2) to phosphatidylinositol-3,4,5-trisphosphate (PI3,4,5-P3), and then recruits downstream AKT to modulate a series of cellular processes. This evidence concerns the gene AKT1 and cancer.