CD274 and neoplasm: Thus, GATA3-AS1 can promote tumor progression by increasing PD-L1 stability.146 When GSK3α phosphorylates PD-L1, Ariadne-1 homolog (ARIH1), a member of the Ariadne family of E3 ubiquitin ligases, ubiquitinates PD-L1 via K48-linked ubiquitin chains, leading to PD-L1 degradation.134