ChIP analysis revealed that MLL1 could bind the PD-L1 promoter and may directly stimulate PD-L1 expression at the transcription level.102 Moreover, H3K4me3 levels flanking the PD-L1 promoter region, as well as PD-L1 expression, can be reduced by silencing MLL1 expression in pancreatic cancer cells. This evidence concerns the gene CD274 and familial pancreatic carcinoma.