In addition, miRNA-200a elevated PD-L1 expression in osteosarcoma cells through PTEN activity, which suppresses CD8+ T cell activation and induces tumor growth.116 Further, miR-375 negatively regulates PD-L1 via the JAK2/STAT3 axis in gastric cancer,117 and miR-27a-3p transported by exosome could remotely promote PD-L1 expression via MAGI2 (Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2)/PTEN signaling in breast cancer.118. This evidence concerns the gene CD274 and breast cancer.