The genomic variant, rs4143815, in the PD-L1 3′-UTR also significantly promotes PD-L1 expression in different cancers.36,37 By sequencing 276 gastrointestinal cancers, including colorectal, esophageal, HCC, gastric, and pancreatic cancers, Wang et al36 discovered that a G-C mutation in the PD-L1 3′-UTR could inhibit miR-570 binding and upregulate PD-L1 expression in gastric cancer. Here, CD274 is linked to familial pancreatic carcinoma.