In non-Schistosoma-associated urinary bladder squamous cell carcinoma, PD-L1 expression was not related to T or N stages.13 Further, PD-L1 expression was an independent marker of clinical stage in nasopharyngeal carcinoma.14 In non-small cell lung cancer (NSCLC), PD-L1 levels were correlated with N, but not T or M stage.15 These data suggest that, in certain types of tumor, PD-L1 level may be related to tumor stage, and could be more significant only in certain stages. The gene discussed is CD274; the disease is bladder squamous cell carcinoma.