However, the comparative growth disadvantage of the S. Typhimurium double importer mutant in Mcoln2 knockout mice contrasting with the comparative growth advantage of wild-type S. Typhi in MCOLN2+/+ human THP-1 cells (see Figure 4G) suggests that mucolipin-2’s impact on Mg2+ availability during infection depends on context, likely including Salmonella serovar and host species as well as the infected cell type or tissue. This evidence concerns the gene MCOLN2 and infection.