IFNG and Pancytopenia: The mechanisms of pancytopenia with HGA are unclear, but some evidence points to pathogen activation of macrophages by proinflammatory cytokines, such as IFNγ in tissue sequestration or destruction (Borjesson et al., 2001; Borjesson et al., 2005a; Dumler et al., 2007; Davies et al., 2011; Dumler, 2012; Scorpio et al., 2018).