While DCs from both strains differentiate with infection to express increased major histocompatibility complex (MHC) and costimulatory molecules, DCs from B6 animals sustain higher infection densities, higher expression levels of MHC class II, IL12, and increased CD4+ T cell priming for gamma interferon (IFNγ) production than do DCs from C3H mice, that develop a suppressive response with a high frequency of Foxp3+ T regulatory cells (Fang et al., 2007). The gene discussed is HLA-C; the disease is infection.