FOXO1 and brain ischemia: Additionally, the expression of miR-182 was found to increase after permanent middle cerebral artery occlusion (pMCAO), and it exacerbated cerebral ischemia injury by targeting inhibitory member of the ASPP family (iASPP) or aggravated blood-brain barrier disruption by downregulating the mTOR/FOXO1 pathway in cerebral ischemia (Yi et al., 2017) (Zhang et al., 2020).