Rancan et al. showed that the expression of miR-182 significantly increased and contribute to pulmonary artery hypertension vascular remodeling via targeting MYADM to regulate KLF4/p21 signaling pathway after I/R in pigs with lung auto-transplantation (Rancan et al., 2016). The gene discussed is KLF4; the disease is pulmonary arterial hypertension.