EZH2 and embryonal carcinoma: One study performed on frozen tissue found a decrease in EZH2 levels in TGCT compared to normal testis, with no significant differences between SGCTs and NSGTs, while the other found high levels of EZH2 in GCNIS and reported its absence in embryonal carcinoma (Almstrup et al., 2010; Hinz et al., 2010).