In a study performed by Yuan and others by assessing the tumor-suppressive function of SETD2 in PCa, it was clearly demonstrated that SETD2 monomethylates EZH2 at its 735 lysine residue, triggering a Smurf2 E3 ligase-dependent degradation (Yuan et al., 2020). This evidence concerns the gene EZH2 and neoplasm.