In recent years, multiple molecular key players for PCa development have been identified, such as androgen receptor (AR), IDH1, FOXA1, TP53, RB1, PTEN, N-myc, ETS family transcription factors, OCT4, SOX2, NANOG, etc. (Robinson et al., 2015; Amin et al., 2017). Here, AR is linked to posterior cortical atrophy.