Methylation at H3K36 refers to di-methylation or tri-methylation, the former being catalyzed by NSD2 which has a role in PCa by modulating Twist family bHLH transcription factor 1 (TWIST1) to promote epithelial to mesenchymal transition and invasiveness in PCa cell lines (Ezponda et al., 2013). The gene discussed is TWIST1; the disease is posterior cortical atrophy.