PTF1A and familial pancreatic carcinoma: Indeed, preclinical studies have shown that pancreatic cancer cells can be induce to differentiate by a key pancreatic differentiation factor Ptf1a, and breast cancer cells can be induced to post-mitotic adipocytes, and leading to suppression of the cancers (Ishay-Ronen et al., 2019; Krah et al., 2019).