As shown in Fig. 6B, the expression levels of HIF-1α were significantly lower in the MA@HF (2.5 ± 0.9%) and MA@PNS-HF (1.3 ± 0.4%) groups than those in the Ctrl (8.7 ± 1.1%), HF (8.7± 1.2%), and PNS-HF (6.1 ± 0.7%) groups. This evidence concerns the gene HIF1A and hydrops fetalis.