Smurf1 has also been implicated in tumor development by ubiquitination of cancer-suppressing proteins (27, 28), in cancer metastasis by suppression of epithelial-mesenchymal cell transition (EMT) pathway (29–31), in pancreatic cancer invasiveness (32, 33), cardiovascular diseases (34), and in liver steatosis (35). Here, SMURF1 is linked to cancer.