In addition to components from the Sindbis virus, it was shown that Smurf1 interacts with the Spike protein from SARS-CoV-2 in HEK293 cells, and mRNA for Smurf1 was found to be overexpressed in swab samples from the nasopharynx and oropharynx of patients positive for COVID-19 (13) (Figure 3), which suggests that Smurf1 might present a relevant role to regulate immune resistance against COVID-19. Here, SMURF1 is linked to COVID-19.