The result of the MR analysis showed that genetically predicted IL-16 [odds ratio (OR): 1.09; 95% confidence interval(CI): 1.00–1.18; p = 0.047] and IL-18 (OR: 1.06; 95% CI: 1.00–1.13; p = 0.044) significantly positively correlated with IBD, and IL-12p70 (OR: 0.89; 95% CI: 0.81–0.97; p = 0.009) significantly negatively correlated with IBD (Figure 1A). This evidence concerns the gene IL18 and inflammatory bowel disease.