In this study, we used MR analysis to assess the two-way causal relationship between multiple ILs (IL-8, IL-12, IL-16, IL-17, IL-18), chemokines (CCL20, CCL23, CCL25, CXCL5, CXCL10, CXCL11), and IBD and its subtypes. This evidence concerns the gene CCL25 and inflammatory bowel disease.