For chemokines, genetically predicted levels of CXCL10 (OR: 1.06; 95% CI: 1.01–1.12; p = 0.024) were associated with the risk of IBD in the IVW model, and CCL23 (OR: 0.94; 95% CI: 0.89–1.00; p = 0.038) was associated with of IBD protection. Here, CXCL10 is linked to inflammatory bowel disease.