The causal relationship between IL-12p70 and CCL23 and IBD has not been reported in the relevant literature, and this study is the first to demonstrate that IL-12p70 and CCL23 reduce the risk of IBD by MR analysis.The studie has only speculated that IL-12p70 affects the body’s inflammatory response by inducing Th1 cells to differentiate and mature during IBD based on the results (25). The gene discussed is CCL23; the disease is inflammatory bowel disease.