The results revealed that DDX58 (1.66 ± 0.80 vs. 1.09 ± 0.48, p = 0.0294), IFIH1 (1.56 ± 0.63 vs. 1.06 ± 0.41, p = 0.0304), IRF7 (2.78 ± 1.25 vs. 1.05 ± 0.37, p < 0.0001), STAT1 (1.67 ± 0.70 vs. 1.06 ± 0.39, p = 0.0116), STAT2 (1.91 ± 0.80 vs. 1.03 ± 0.26, p = 0.0013), ADAR (1.44 ± 0.47 vs. 1.03 ± 0.25, p = 0.0027), and TRIM25 (1.53 ± 0.41 vs. 1.02 ± 0.20, p = 0.0005) were elevated in the monocytes of patients with IIM (Figure 8A). The gene discussed is IFIH1; the disease is acquired idiopathic inflammatory myopathy.