The ROC analysis indicated that IRF7 (AUC = 0.9145, 95%CI = 0.8001–1.0000) expressed by monocytes had a high accuracy in the diagnosis of IIM (Figure 8C), and monocyte-expressed STAT1 (AUC = 0.7650, 95%CI = 0.5672–0.9627), STAT2 (AUC = 0.8611, 95%CI = 0.7115–1.0000), IFIH1 (AUC = 0.7262, 95%CI = 0.5314–0.9209), DDX58 (AUC = 0.7183, 95%CI = 0.5348–0.9017), ADAR (AUC = 0.8056, 95%CI = 0.6510–0.9601), and TRIM25 (AUC = 0.8968, 95%CI = 0.7895–1.0000) demonstrated a moderate value in the diagnosis of patients with IIM (Figure 8C). This evidence concerns the gene IRF7 and acquired idiopathic inflammatory myopathy.