As shown in Figure 6A, the upregulation of IRF7 (1.51 ± 0.99 vs. 1.06 ± 0.36, p = 0.0044), STAT1 (1.27 ± 0.58 vs. 1.06 ± 0.39, p = 0.0126), and MNDA (1.27 ± 0.44 vs. 1.02 ± 0.17, p = 0.0008) and the downregulation of ADAR (0.95 ± 0.41 vs. 1.01 ± 0.16, p = 0.0480) and TBX21 (0.49 ± 0.38 vs. 1.07 ± 0.44, p < 0.0001) were detected in patients with IIM compared with HCs. Here, IRF7 is linked to acquired idiopathic inflammatory myopathy.