OCLN and chronic kidney disease: Consistent with these observations, another GPR40 agonist, GW9508, has been shown to prevent cytokine-induced airway epithelial barriers disruption of claudin, occludin, and ZO-1 (Moonwiriyakit et al., 2019), and Factor Xa inhibition has been shown to reduce EMT in chronic kidney disease (Fang et al., 2022).