The results of analyses based on a GWAS study revealed that the overlapping genes involved in three roots including acne vulgaris pathology pathway, TGFβ signaling pathway, and isotretinoin action pathway (300 genes in total) are 36 genes, among them, IL6, FAS, and IFNG genes were the most potential candidates because of their overlapping link in all three mentioned roots. The gene discussed is IFNG; the disease is acne.