In addition, obesity is established risk factors of CRC (61, 62), through DNA methylation spectrum(Illumina InfiniumHumanMethylation450 BeadChip) epigenetic changes, estimate the FGF18 was associated with a significant CRC, May be an important intermediate biomarker for obesity and CRC (63). The gene discussed is FGF18; the disease is obesity due to melanocortin 4 receptor deficiency.