Moreover, it can inhibit ccRCC cell proliferation and epithelial-mesenchymal transition by reducing the phosphorylation level of PI3K/AKT and the protein expression of EMT-related markers and transcription factors.Moreover, the protein levels of E-cadherin were increased, while the protein levels of Vimentin and N-cadherin were decreased by overexpression of FGF18, which was verified in the xenograft model in vivo (149). The gene discussed is FGF18; the disease is nonpapillary renal cell carcinoma.