Western blot analysis showed that the phosphorylation of MAPK and PI3K/AKT in Caco-2 and LT97 cells was activated by human recombinant FGF18, which stimulated the proliferation and angiogenesis of CRC cells, and was also attenuated by the decreased intracellular expression of FGF18 (64). This evidence concerns the gene FGF18 and colorectal carcinoma.