In addition, the mRNA levels of tumor migration factors TGF-β, MMP-9 and MMP-2 as well as epithelial-mesenchymal transition (EMT) markers N-cadherin, vimentin, Snail-1, Snail-2 and TIMP-1 were also significantly up-regulated by FGF18 stimulation. The gene discussed is FGF18; the disease is neoplasm.