For example, in the interaction of FGF18 with its receptor FGFR, in an in vitro irinotecan(IRI) -induced apoptosis model of CRC cells such as Caco2 and HCT116, FGF18 markedly enhanced cell viability as measured by SRB assay through the FGFR3-IIIc pathway and reversed IRI-induced cell cycle arrest as well as apoptosis in SW480 cells (66). This evidence concerns the gene FGFR3 and colorectal carcinoma.