Through IF, co-IP, and nucleocytoplasmic protein separation assays, it was proved that HDAC7 promoted the proliferation and migration of NSCLC by reducing the phosphorylation of β-catenin at Ser45 and the acetylation of β-catenin at Lys49 and promoting its nuclear translocation and accumulation, then combined with TCF4 to regulate FGF18 to promote the proliferation and migration of NSCLC (126). This evidence concerns the gene TCF4 and non-small cell lung carcinoma.