In line with previous studies which were carried out with different technologies for protein detection and quantification (17, 23–28), high plasma levels of AGRP, FGF21, midkine (MDK), C-C motif chemokine ligand 20 (CCL20), IL6, and CSF3 as well as reduced ribonucleotide reductase regulatory TP53 inducible subunit M2B (RRM2B) on plasma level of CRC patients were also identified in our study. This evidence concerns the gene RRM2B and colorectal carcinoma.