Next, to distinguish which of the protein changes were a consequence of an altered secretion from a certain type of cells and which were a result of destructed tissues or cells released during CRC tumorigenesis, from the 202 DEPs, 50 proteins were identified in the human blood secretome from Human Protein Atlas, including cytokines that modulate the immune responses within the TME, such as IFNG, IL6, IL15, CCL20, CXCL9, and CCL23 (Supplementary Table 6). This evidence concerns the gene IL15 and colorectal carcinoma.