Importantly, we found novel protein changes including high levels of oncogenic proteins such as R-Spondin 3 (RSPO3) and secernin 1 (SCRN1) as well as low levels of tumor suppressors such as Ret proto-oncogene (RET) and Rho guanine nucleotide exchange factor 12 (ARHGEF12) in CRC patients. This evidence concerns the gene ARHGEF12 and neoplasm.