EPAS1 and neoplasm: TF factor motif analysis within H3K27ac peaks revealed 29 MG63-specific TF binding sites, including those for EOMES, PRDM1, EPAS1 (HIF2A), E2F6, and MYC/MAX, which reflect known early development, tumor-initiation, and stemness factors (Figure 4B, Worksheet 1) (65).