SOD2 and osteosarcoma: Nevertheless, despite these limitations, based on the reanalysis of cDNA array data, SOD2 levels were consistently enhanced in metastatic OS samples, yet decreased relative to normal bone tissue, once again suggesting that SOD2 plays an upstream adaptive role in osteosarcomas and stimulation of its anti-oxidative organelle-specific functions may be key to therapy (Figures S11, S12).