In the CNS, 5-HT1A receptors are mainly located in the hippocampus, nasal septum, amygdala, and cortical limbus and act as both autoreceptors and heteroreceptors, which makes it a therapeutic target for depression, anxiety, schizophrenia, pain, cognitive impairment, and neurodegenerative diseases. Here, HTR1A is linked to depressive symptom measurement.