Primary immunodeficiency, linoleic acid metabolism, and DNA replication were significantly enriched in the high TLR2 subgroup, while pantothenate and CoA biosynthesis, biosynthesis of lactose and neolactone series of glycosphingolipids, and the complement and cohesive cascade were significantly enriched in the low TLR2 subgroup. This evidence concerns the gene TLR2 and inborn error of immunity.