Some known lung cancer susceptibility loci were also showed association with trajectory scores, such as NPAS3 locus (rs7154051, significant level P = 1.19e-07), DSCAM locus (rs1569094034, significant level P = 5.54e-07) and VLDLR-AS1 locus (rs7029746, significant level P = 1.15e-06) [23]. The gene discussed is NPAS3; the disease is lung cancer.