HSP90AB1 and cystic fibrosis: Our results demonstrate that the yeast system may be used to dissect how Hsp90 and cochaperones cooperate during the folding cycle, and may provide new insights into prior studies that show that overexpression or deletion of human cochaperones homologous to Hch1 and Cpr6 have opposing effects in models of neurodegenerative disease and cystic fibrosis [19,20].