GLP1R and Anxiety: With respect to stress and anxiety, we identified Glp1r, which directly interacts with the HPA axis to trigger the secretion of glucocorticoids (Ghosal et al. 2013) and Gpr3 which modulates anxiety- and depressive-related behaviors by regulating monoaminergic neurotransmitters and their metabolites (Valverde et al. 2009).