MEFV and Arthritis: The final model identified that the independent determinants of colchicine resistance were the age at symptom onset ≤3 years [odds ratio (OR) 1.6 (95% CI 1.2, 2.2), P = 0.003], attack frequency before diagnosis ≥1/month [OR 1.8 (95% CI 1.3, 2.4), P < 0.001], arthritis [OR 2.3 (95% CI 1.6, 3.1), P < 0.001], chest pain [OR 1.6 (95% CI 1.1, 2.2), P = 0.009] and homozygosity or compound heterozygosity for exon 10 MEFV mutations [OR 4.4 (95% CI 2.8, 7.2), P < 0.001].