Being seropositive for ShTAL3-IgE (GM ratio: 0.48; 95% CI: 0.25–0.94; p = 0.03) was negatively associated with baseline infection intensity in cross-sectional models of anti-ShTAL responses and infection intensity (as measured by CAA), that accounted for age, village of residence and the relevant TAL-specific IgG4 response. Here, IGHE is linked to infection.