Further, additional parameters belonging to CD4+ T cell activation TCD4, growth of B cells γB, death of activated APCs δAPC, differentiation of B cells into antibody-secreting plasma cells TBC, potency of the injected antigen to activate naive APCs Kv, and activation of naive B cells TB were also observed to have a moderate effect on antibody titer (Figure 4). Here, CD4 is linked to tuberculosis.