VEGFA and von Hippel-Lindau disease: HIF inhibition may also be effective for retinal vascular diseases in which HIFs and/or retinal ischemia plays a central role, but for which anti-VEGF therapies have proven inadequate, including von Hippel–Lindau disease (63, 64), Coats disease (65, 66), Norrie’s disease (67, 68), and familial exudative vitreoretinopathy (FEVR) (69).