As in PD, iron may directly act on α-synuclein and may provoke an insoluble molecular structure (Riederer et al. 2019; Lee and Lee 2019), which aggregates as glial cytoplasmic inclusions (Probst-Cousin et al. 1998), or iron induces oxidative stress mechanisms which may contribute to disturbances of glial function and finally neuronal death. Here, SNCA is linked to Parkinson disease.