Lamers et al. found that there was no difference in IL-6, IL-8, IL-10, IL1b or TNF-a in a mixed linear model but that a transient increase in both IL-6 and IL-10 was observed between IBD-walkers and non-IBD non-walkers at baseline and post day 1 exercise during a 4-day walking march. This evidence concerns the gene TNF and inflammatory bowel disease.