WNK2 and neoplasm: Curcumol, as an important active component of Curcuma, extracts from numerous plants of family Zingiberaceae, has the effects of inhibiting tumor growth, cell cycle arrest, and promoting apoptosis in a variety of tumor cells via targeting the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK), phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathways [4, 5].